A symposium, "Modeling Tumor Expression Profiles for Intervention," will be presented by Roswell Park Cancer Institute (RPCI) November 5-6, 8 am-4:15 pm, Hilleboe Auditorium, Research Studies Center, Buffalo, New York.

John Cowell, PhD, DSc, Chair, Department of Cancer Genetics, RPCI, and Enrico Mihich, MD, Sr. Advisor to the President, Department of Pharmacology & Therapeutics, RPCI, are symposium chairmen.

This symposium will focus on the technologies that address issues of complexity in the regulation of tumor cell populations and simplify them.

The role of genetic mechanisms in determining tumor behaviors will be discussed in relation to the functional consequences of different gene expression profiles. The molecular and cellular mechanisms of tumor escape from microenvironmental and systemic control mechanisms will be related to the genetic expression profiles of tumor and host.

The symposium will conclude with a discussion of the clinical relevance of the topics covered.

Invited presenters include: Stephen Baylin, MD, The Johns Hopkins School of Medicine; Gary Churchill, PhD, Jackson Laboratory; Joe Gray, PhD, University of California, San Francisco Comprehensive Cancer Center; Andre Gudkov, PhD, Cleveland Clinic Foundation; Jeffrey Hager, PhD, University of California, San Francisco; Eric Holland, MD, PhD, Memorial Sloan-Kettering Cancer Center; Olli Kallioniemi, MD, PhD, National Institutes of Health; Stanley Korsmeyer, MD, Dana Farber Cancer Institute, Harvard Medical School, Howard Hughes Medical Institute.

Also, Raju Kucherlapati, PhD, Albert Einstein College of Medicine, Harvard Medical School, Harvard-Partners Center for Genetics and Genomics; Francesco Marincola, MD, National Cancer Institute; Sanford Markowitz, PhD, Howard Hughes Medical Institute, Case Western Reserve University; Charles Sawyers, MD, UCLA-University of California at Los Angeles School of Medicine; Dennis Slamon, MD, PhD, UCLA- University of California at Los Angeles School of Medicine; Victor Velculescu, MD, PhD, The Johns Hopkins Oncology Center and William Weiss, MD, PhD, University of California, San Francisco.

"Modeling Tumor Expression Profiles For Intervention" is supported by unrestricted educational grants from Abbott Laboratories, Hoffman-LaRoche and Merck Research Laboratories. To register or for more information, call (716) 845-3095.

Roswell Park Cancer Institute, founded in 1898, is the nation's first cancer research, treatment and education center and is the only National Cancer Institute-designated comprehensive cancer center in Western New York.

[Contact: Deborah Pettibone]

18-Oct-2001